INSPIRE theme “Human Health and Safety” data set, which provides information on general health indicators and health care statistics in the Republic of Lithuania, mortality by disease, lifestyle of children and adults, environmental aspects related to human health and safety (bathing water quality, noise emissions data and accidents). We note that the values of adult lifestyle monitoring indicators were obtained by interviewing and summarizing 24,889 adults older than 18 years, and the values of child lifestyle monitoring indicators were obtained by interviewing 38,633 school-age children (grades 5.7 and 9). The data providers of the INSPIRE theme “Human Health and Safety”, the section “Environmental Health Determinants” are the Ministry of Health of the Republic of Lithuania, the Center for Health Training and Disease Prevention, and the section “Security” is provided by the Police Department under the Ministry of the Interior.